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研究の動向目次へ
updated 2009.12.18

目 次

A: 結核菌(抗酸菌)関連 D:西欧の結核
B: 宿主反応関連
C: ヒト遺伝/免疫/疫学





A: 結核菌(抗酸菌)関連

2009.No.8 (updated 2009.12.18)

著者名 Brown,A.K.,Taylor'R.C.,Bhatt,A.,et al
タイトル Platensimycin Activity against Mycobacterial b-Ketoacyl- ACP Synthases.
雑誌名 PLoS ONE 4(7): e6306,2009 (表2、図6、文献35)

2009.No.7 (updated 2009.4.19)

著者名 Singh, R., Manjunatha, U., Boshoff, H. I., et al.
タイトル PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
雑誌名 Science, 2008, 322: 1392 – 1395 (表1、図3、文献25)

2009.No.5 (updated 2009.3.23)

著者名 Zuber, B., Chami, M., Houssin, C., et al.
タイトル Direct visualization of the outer membrane of Mycobacteria and Corynebacteia in their native state.
雑誌名 J. Bacteriology, 190; 5672-5680, 2008.(図7、表1、文献59)

2009.No.4 (updated 2009.3.23)

著者名 Hoffmann, C., Leis, A., Niederweis, M., et al.
タイトル Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure.
雑誌名 PNAS, 105; 3963-3967, 2008. (図5、表0、文献44)

2009.No.1 (updated 2009.3.23)

著者名 Vandal, O.H., Pierini, L.M., Schnappinger, D., et al.
タイトル A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.
雑誌名 Nat. Med, 2008, 14: 849 – 854 (表0、図4、文献40)

2008.No.4 (updated 2008.3.26)

著者名 Kaku, T., Kawamura, I., Uchiyama, R., Kurenuma, T., and Mitsuyama, M.
タイトル RD1 region in mycobacterial genome is involved in the induction of necrosis in infected RAW264 cells via mitochondrial membrane damage and ATP depletion.
雑誌名 FEMS Microbiol. Lett., 2007, 274: 189-195 (図5、表1、文献21)

2007.No.16 (updated 2007.8.7)

著者名 Harth, G., Zamecnik, P.C., Tabatadze, D., et al.
タイトル Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis.
雑誌名 PNAS, 2007, 104: 7199-7204, (図5、表1、文献17)


2007.No.15 (updated 2007.8.7)

著者名 Newton, S.M., Smith, R.J., Wilkinson, K.A., et al.
タイトル A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion.
雑誌名 PNAS, 2006, 103: 15594-15598 (図4、表0、文献25)


2007.No.14 (updated 2007.8.7)

著者名 Robinson, N., Wolke, M., Ernestus, K., and Plum, G.
タイトル A mycobacterial gene involved in synthesis of an outer cell envelope lipid is a key factor in prevention of phagosome maturation .
雑誌名 Infect. Immun., 2007, 75: 581-591,(図11、表0、文献43)


2007.No.9 (updated 2007.1.25)

著者名 Raman, S., Puyang, X., Cheng, T.Y., et al.
タイトル Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis.
雑誌名 J. Bacteriol., 2006; 188: 8460-8.(図6、表2、文献53)


2007.No.8 (updated 2007.1.25)

著者名 Champion, P.A., Stanley, S.A., Champion M.M., et al.
タイトル C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.
雑誌名 Science, 2006; 313: 1632-36(図3、表1、文献27)


2007.No.4 (updated 2007.1.25

著者名 Mokrousov, I., Jiao, W.W., Valcheva, V., et al.
タイトル Rapid detection of the Mycobacterium tuberculosis Beijin genotype and its ancient and modern sublineages by IS6110-based inverse PCR.
雑誌名 J. Clin. Microbiol., 2006, 44; 2851-2856.(図2、表0、文献32)


2006.No.16 (updated 2006.12.26)

著者名 Moore, D. A. J.. Evans, C. A. W.. Gilman, R. H., et al.
タイトル Microscopic-observation drug-susceptibility assay for the diagnosis of TB
雑誌名 N. Engl. J. Med. 2006; 355: 1539-50(図3、表2、文献42)


2006.No.15 (updated 2006.12.26)

著者名 Sharma, K., Gupta, M., Pathak, M., et al.
タイトル Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo
雑誌名 雑誌名 J. Bacteriol, 2006; 188: 2936-2944(図4、表1、文献40)


2006.No.12 (updated 2006.8.25)

著者名 Filliol, I., Alofiya, S., Cavatore, M., et al.
タイトル Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: Insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set
雑誌名 J. Bacteriol., 2006; 188: 759-772 (図8、表4、文献72)


2006.No.11 (updated 2006.8.25)

著者名 Rodriguez, G. M. and Smith, I.
タイトル Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis.
雑誌名 J. Bacteriol. 2006, 188: 424-430, (図6、表0、文献24)


2006.No.9 (updated 2006.8.11)

著者名 Fol, M., Chauhan, A., Nair, N. K., et al.
タイトル Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator.
雑誌名 Mol. Microbiol., 2006, 60: 643 - 657 (図8、表1、文献81)

2006.No.6 (updated 2006.5.12)

著者名 Gao, L-Y., Pak, M., Kish, R., et al.
タイトル A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages.
雑誌名 Infect. Immun., 2006, 74: 1757-1767.,(図9、表3、文献34)

2006.No.3 (updated 2006.1.10)

著者名 Dario Garcia de Viedma, et al.
タイトル Association between the infectivity of Mycobacterium tuberculosis strains and their efficiency for extrarespiratory infection
雑誌名 J.I.D., 2005, 192: 2059-2065, (図2、表2、文献24)

2006.No.2 (updated 2006.1.10)

著者名 Cohen-Gonsaud M, et al.
タイトル The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes
雑誌名 Nature Structural & Molecular Biology、2005, 12: 270-273,(図3、表1、文献21)

2006.No.1 (updated 2006.1.10)

著者名 Liem Nguyen, et al.
タイトル FbpA-Dependent biosynthesis of trehalose dimycolate is required for the intrinsic multidrug resistance, cell wall structure, and colonial morphology of Mycobacterium smegmatis
雑誌名 J. Bacteriol., 2005, 187, 6603-6611 (図5、表1、文献40)

2005.No.11 (updated 2005.11.25)

著者名 Papavinasasundaram KG, et al
タイトル Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice
雑誌名 J Bacteriol., 2005, 187: 5751-5760, (図5、表2、文献58)

2005.No.10 (updated 2005.11.22)

著者名 Danielle Charlet , Serge Mostowy, et al
タイトル Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK
雑誌名 Molecular Microbiology 、2005, 56(5): 1302-1313(図4、表4、文献75)

2005.No.8 (updated 2005.11.01)

著者名 Tian, J., Bryk, R., Itoh, M., Suematsu, M., and Nathan, C.
タイトル Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: 
Identification of α-ketoglutarate decarboxylase.
雑誌名 PNAS、2005, 102: 10670-10675 (図4、表2、文献48)

2005.No.7 (updated 2005.9.28)

著者名 Roberto Colangeli, et al
タイトル The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol
雑誌名 Molecular Microbiology 、2005, 55(6): 1829-1840(図7、表1、文献47)

 2005.No.5 (updated 2005.9.28)

著者名 Munoz-Elias EJ, and McKinney JD
タイトル Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence.
雑誌名 Nature Medicine, 2005, 11: 638-644, (図6、表0、文献48)

  2005.No.2 (updated 2005.9.28)

著者名 Liana Tsenova et al.
タイトル Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
雑誌名 J. Infect. Dis., 192:98-106, 2005.(図5、表0、文献46)

2005.No.1(updated 2005.9.28)

著者名 Richman, L., et al
タイトル A member of the cAMP receptor member protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor.
雑誌名 Mol. Microbiol., 2005, 56: 1274-1286, (図6、表2、文献44)




B: 宿主反応関連

2009.No.9 (updated 2009.12.18)

著者名 Koh, K.W., Soh, S. E, and Seah, G. T.
タイトル Strong antibody responses to Mycobacterium tuberculosis PE-PGRS62 protein are associated with latent and active tuberculosis.
雑誌名 Infection and Immunity, 2009 77: 3337 - 3343 (表0,図5,文献24)

2009.No.3 (updated 2009.3.23)

著者名 Sieling P.A., Hill P.J., Dobos K.M. et al.
タイトル Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restiricted T cell activation.
雑誌名 J. Immunol, 2008, 180: 5833-5842 (表0、図6、文献47)

2009.No.2 (updated 2009.3.23)

著者名 Martomeau A.R., Wilkinson K.A., Newton S. M., et al.
タイトル IFN-γ- and TNF-independent vitamin D-inducible human suppression of Mycobacteria: the role of cathelicidin LL-37
雑誌名 J. Immunol. 2007, 178: 7190-7098 (表1、図7、文献52)

2008.No.3 (updated 2008.3.26)

著者名 Li, L., Lao, S.H., Wu, C.Y.
タイトル Increased frequency of CD4+CD25high Treg cells inhibit BCG-specific induction of IFN-γby CD4+ T cells from TB patients.
雑誌名 Tuberculosis, 2007, 87: 526-534,(図5、表1、文献39)

2008.No.2 (updated 2008.3.26)

著者名 Scott-Browne, J.P., Shafiani, S., Tucker-Heard, G., et al.
タイトル Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis.
雑誌名 J. Exp. Med., 2007, 204: 2159-2169,(図6、表0、文献57)

2008.No.1 (updated 2008.3.26)

著者名 Ordway, D., Higgins, D. M., Sanchez-Campillo, J., et al.
タイトル XCL1 (Lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-γ by CD4 T cells and participates in granuloma stability.
雑誌名 J. Leukoc. Biol., 2007, 82: 1221 - 1229 (図6、表0、文献30)

2007.No.23 (updated 2007.12.10)

著者名 Pathak, S.K., Basu, S., Basu, K.K., et al.
タイトル Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.
雑誌名 Nature Immunology 2007, 8: 610-618,(図9、表0、文献50)

2007.No.22 (updated 2007.12.10)

著者名 Goletti, D., Parracino, M.P., Butera, O., et al.
タイトル Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study.
雑誌名 Respir Res. 2007; 8: 5.(図3、表3、文献34)


2007.No.21 (updated 2007.8.7)

著者名 Pompei, L., Jang, S., Zamlynny, B., Tavikumar, S., McBride, A., et al.
タイトル Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of direct TLRs.
雑誌名 J. Immunol., 2007, 178: 5192-5199(図8、表0、文献50)


2007.No.20 (updated 2007.8.7)

著者名 Huang, D., Qiu, L., Wang, R., Lai, X., Du, G., et al.
タイトル Immune gene networks of mycobacterial vaccine-elicited responses and immunity.
雑誌名 J. Infect. Dis., 2007, 195:55-69、 (図1、表4、文献40)


2007.No.19 (updated 2007.8.7)

著者名 Stubbe, M., Vanderheyde, N., Golman, M., and Marchant, A.
タイトル Antigen-specific central memory CD4+ T lymphocytes produce meultiple cytokines and proliferate in vivo in humans.
雑誌名 J. Immunol., 2006, 177: 8185-8190


2007.No.18 (updated 2007.8.7)

著者名 Kamath, A., Woodworth, JA., and Behar, S.M.
タイトル Antigen-specific CD8+T cells and the develoopement of central memory during Mycobacteium tuberculosis infection.
雑誌名 J. Immunol., 2006, 177: 6361-6369 (表0、図6、文献45)


2007.No.17 (updated 2007.8.7)

著者名 Alonso, S., Pethe, K., Russell, D.G., and Purdy, G.E.
タイトル Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy.
雑誌名 PNAS、2007, 104: 6031-6036 (図5、表0、文献41)


2007.No.13 (updated 2007.8.7)

著者名 Wu, B., Huang, C., Kato-Maeda, M., et al.
タイトル Messenger RNA expression of IL-8, FOXP3, and IL-12β differentiates latent tuberculosis infection from disease.
雑誌名 J. Immunol., 2007, 178: 3688-3694,(図4、表1、文献25)

2007.No.12 (updated 2007.7.9)

著者名 Guyot-Revol, V., Innes, J.A., Hackforth S., et al.
タイトル Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis.
雑誌名 Am. J. Respir. Crit. Care Med., 2006, 173: 803-810,(図5、表2、文献45)

2007.No.11 (updated 2007.3.26)

著者名 Raqib, R., Rahman, J., Kamaluddin, A. K. M., et al.
タイトル Rapid diagnosis of active tuberculosis by detecting antibodies from lymphocyte secretion.
雑誌名 Journal of Infectious Diseases. 2003, 188: 364-70,(図4、表0、文献45)

2007.No.10 (updated 2007.1.25)

著者名 Neyrolles, O., Hernandez-Pando, R., Pietri-Rouxel, F., et al.
タイトル Is adipose tissue a place for Mycobacterium tuberculosis persistence?
雑誌名 PLoS ONE. 2006; 1: e43.,(図3、表2、文献38)

2007.No.7 (updated 2007.1.25)

著者名 Makino, M., Maeda, Y., and Inagaki, K.
タイトル Immunostimulatory activity of recombinant Mycobacterium bovis BCG that secretes major membrane protein II of Mycobacterium leprae
雑誌名 Infect. Immun., 2006, 74; 6264-6271.(図6,文献30)

2007.No.6 (updated 2007.1.25)

著者名 Leyten, E.M., Lin, M.Y., Franken, K.L., et al.
タイトル Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.
雑誌名 Microbes Infect., 2006, 8: 2052-2060,(図4、表1、文献34)

2007.No.5 (updated 2007.1.25)

著者名 Loeuillet, C., Martinon, F., Perez, C., et al.
タイトル Mycobacterium tuberculosis subverts innate immunity to evade specific effectors.
雑誌名 J. Immunol., 2006, 177: 6245-6255 (図8、表0、文献73)

2007.No.3 (updated 2007.1.25)

著者名 Santosuosso, M., McCormick, S., Zhang, X., et al.
タイトル Intranasal boosting with an adenovirus-vectored vaccine markedly enhances protection by parenteral Mycobacterium bovis BCG immunization against pulmonary tuberculosis.
雑誌名 Infec. Immun., 2006; 74: 4634-4643. (図7、表0、文献26)

2006.No.14 (updated 2006.11.21)

著者名 Tan, B. H., Meinken, C., Bastian, M., et al.
タイトル Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens.
雑誌名 Journal of Immunology, 2006, 177: 1864-1871.(図5、表0、文献44)

2006.No.13 (updated 2006.9.23)

著者名 Cruz, A., Khader, S.A., Torrado, E., et al.
タイトル Cutting edge: IFN-γ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection.
雑誌名 J Immunol., 2006, 177: 1416-1420, (図4、表1、文献38)

2006.No.10 (updated 2006.8.11

著者名 Liu, P.T., Stenger, S., Li, H, Wenzel, L., et al.
タイトル Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
雑誌名 Science, 2006, 311: 1770-1773(図4、表0、文献20)

2006.No.8 (updated 2006.6.5)

著者名 Ghosh, S., Chackerian, A.A., Parker, C.M., et al.
タイトル The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection.
雑誌名 J. Immunol., 2006, 176: 4914 - 4922 (図8、表1、文献51)

2006.No.5 (updated 2006.3.20)

著者名 Murray, R. Z., Kay, J. G., Sangermani, D. G., et al.
タイトル A role for the phagosome in cytokine secretion.
雑誌名 Science, 2005, 310: 1492-1495 (図4、表0、文献24)

2006.No.4 (updated 2006.3.16)

著者名 Bafica, A., Scanga, C. A., Feng, C. G., et al.
タイトル TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.
雑誌名 J.E.M., 2005, 202: 1715-1724,(図6、表0、文献63)

 2005.No.12 (updated 2005.11.30)

著者名 Kang PB, et al
タイトル The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis.
雑誌名 J. Exp. Med., 2005, 202: 987-999. (図9、表0、文献60)

 2005.No.6 (updated 2005.9.28)

著者名 Krutzik SR, et al
タイトル TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.
雑誌名 Nature Medicine, 2005, 11: 653-660, (図6、表0、文献43)




C: ヒト遺伝/免疫/疫学

2009.No.6 (updated 2009.3.23)

著者名 Hershkovitz, I., Donoghue, H.D., Minnikin, D.E., et al.
タイトル Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean.
雑誌名 PLoS ONE 3(10): e3426. doi:10.1371/journal.pone.0003426, (図3、表2、文献51)

2007.No.2 (updated 2007.1.25)

著者名 Wright A., Bai G., Barrera L., et al.
タイトル Emergence of Mycobacterium tuberculosis with extensive resistant to second-line drugs---worldwide, 2000-2004.
雑誌名 MMWR, 2006,55:301-305(表2,文献10)

2007.No.1 (updated 2007.1.25)

著者名 Gandhi, N., Moll, A., Sturm, A., et al.
タイトル Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa.
雑誌名 The Lancet, 2006, 368:1575-1580(図1,表2,文献46)

2006.No.7 (updated 2006.6.5)

著者名 Demissie, A., Wassie, L., Abebe, M., et al. 
タイトル The 6-kilodalton early secreted antigenic target-responsive, asymptomatic contacts of tuberculosis patients express elevated levels of interleukin-4 and reduced levels of gamma interferon.
雑誌名 Infection and Immunity. 2006, 74: 2817-2822, (図4、表0、文献38)

2005.No.9 (updated 2005.11.18)

著者名 Kampmann B., Hemingway C., Stephens A., et al.
タイトル Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ.
雑誌名 J. Clin. Invest. 2005; 115: 2480-2488(図5、表1、文献42)

 2005.No.4 (updated 2005.9.28)

著者名 Tso HW, Ip WK, Chong WP, Tam CM, Chiang AK, Lau YL
タイトル Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese
雑誌名 Genes Immun、2005, 6(4):358-63 (図1、表6、文献26)

  2005.No.3 (updated 2005.9.28)

著者名 Kamio K et al
タイトル Promoter analysis and abberant expression of the MUC5B genes in diffuse panbronchiolitis
雑誌名 Amer. J. Respir. Crit. Care. Med., 2005, 171, 949‐957, (図8、表4、文献41)